Umbralisib

SKU: orb1302401

Description

Umbralisib (TGR-1202) is a selective small molecule inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3Kδ). It is utilized in preclinical research for studying hematological malignancies, demonstrating activity in both in vitro cellular assays and in vivo models of B-cell lymphomas.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1532533-67-7
• MW: 571.55
• Purity: 99.56% (May vary between batches)
• Formula: C₃₁H₂₄F₃N₅O₃
• SMILES: CC(C)Oc1ccc(cc1F)-c1nn([C@@H](C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
• Target: PI3K,Casein Kinase
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (5.77 mM);DMSO:91 mg/mL (159.22 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RP 5264, RP5264, RP-5264, TGR 1202, TGR1202, TGR-1202, PI3Kδ, PI3K, Phosphoinositide 3-kinase, Umbralisib, inhibit, orally active, lymphoma, lymphocytic leukemia, Inhibitor, haematological malignancies, cancer, Casein Kinase, CLL T cells

Quick Database Links

Gene Symbol

PI3K,Casein Kinase