UNC2881

SKU: orb1223282

Description

UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.

Key Properties

• CAS Number: 1493764-08-1
• MW: 463.58
• Purity: >98% (HPLC)
• Formula: C₂₅H₃₃N₇O₂
• SMILES: CCCCNc1ncc(c(N[C@@H]2CC[C@H](CC2)O)n1)C(=O)NCc1ccc(n2ccnc2)cc1
• Target: AChR
• Solubility: DMSO : ≥ 44 mg/mL; 94.91 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UNC2881, UNC-2881, UNC 2881

Quick Database Links

Gene Symbol

AChR