Venetoclax

SKU: orb1306442

Description

Venetoclax (ABT-199) is a highly potent and selective oral Bcl-2 inhibitor (Ki<0.01 nM) with significantly lower affinity for Bcl-xL. It induces apoptosis and autophagy, making it a key tool for cancer research in both in vitro and in vivo models, particularly for studying hematological malignancies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1257044-40-8
• MW: 868.44
• Purity: 98.00% (May vary between batches)
• Formula: C₄₅H₅₀ClN₇O₇S
• SMILES: O=C(C1=CC=C(N2CCN(CC2)CC3=C(CC(C)(CC3)C)C4=CC=C(Cl)C=C4)C=C1OC5=CC6=C(NC=C6)N=C5)NS(=O)(C7=CC=C(C([N+]([O-])=O)=C7)NCC8CCOCC8)=O
• Target: Autophagy,Bcl-2 Family
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (11.51 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:257.5 mg/mL (296.51 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Venetoclax, Inhibitor, GDC0199, GDC-0199, GDC 0199, inhibit, orally, ABT199, ABT-199, ABT 199, Autophagy, Bcl-2 Family, Bcl-2, bioavailable

Quick Database Links

Gene Symbol

Autophagy,Bcl-2 Family