VER-155008

SKU: orb1226944

Description

A potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78; shows cellular activity in HCT116 cells (GI50= 5uM), has similar potencies in both Grp78 and Hsp70; inhibits the proliferation of human breast and colon cancer cell lines with GI50s of 5.3-14.4 uM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells; induced caspase-3/7 dependent apoptosis in BT474 cells.

Key Properties

• CAS Number: 1134156-31-2
• MW: 556.4006
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₃Cl₂N₇O₄
• SMILES: O[C@@H]([C@H]([C@H](N1C(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C(N=CN=C31)N)O4)O)[C@H]4COCC5=CC=C(C#N)C=C5
• Target: HSP
• Solubility: DMSO: ≥ 37 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VER-155008 | VER 155008 | VER155008

Quick Database Links

Gene Symbol

HSP