Withanolide A

SKU: orb1297175

Description

Withanolide A is a natural steroidal lactone shown to prolong lifespan in a C. elegans model of EGFR-driven cancer. This compound is utilized in aging and oncology research, with applications in both in vivo longevity studies and in vitro investigations of its anti-proliferative mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 32911-62-9
• MW: 470.60
• Purity: 98.49% (May vary between batches)
• Formula: C₂₈H₃₈O₆
• SMILES: [H][C@@]12CC[C@H]([C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H]2O[C@@H]2[C@@]2(O)CC=CC(=O)[C@]12C
• Target: NF-κB,Apoptosis,TNF,Gamma-secretase,EGFR
• Solubility: DMSO:55.00 mg/mL (116.87 mM);10% DMSO+90% Corn Oil:1.67 mg/mL (3.55 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NFkB, NF-kB, NFκB, NF-κB, EGFR, Inhibitor, Withanolide A, TNF-α

Quick Database Links

Gene Symbol

NF-κB,Apoptosis,TNF,Gamma-secretase,EGFR