WZ-3146

SKU: orb1300517

Description

WZ3146 is a potent, mutant-selective irreversible inhibitor targeting EGFR(L858R) and EGFR(E746_A750) with IC50 values of 2 nM each, while sparing ERBB2 phosphorylation (T798I). It is a valuable chemical probe for studying oncogenic EGFR signaling in both cellular and animal models of non-small cell lung cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1214265-56-1
• MW: 464.95
• Purity: 97.15% (May vary between batches)
• Formula: C₂₄H₂₅ClN₆O₂
• SMILES: CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)cc1
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:86 mg/mL (184.97 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (E746_A750), EGFR (E746_A750/T790M), ErbB-1, Epidermal growth factor receptor, HER1, Inhibitor, WZ3146, WZ-3146, WZ 3146

Quick Database Links

Gene Symbol

EGFR