WZ8040

SKU: orb1300516

Description

WZ8040 is a novel, irreversible EGFR inhibitor that selectively targets the T790M mutant while sparing ERBB2 phosphorylation (T798I). It is a valuable research tool for studying resistant non-small cell lung cancer in both in vitro and in vivo experimental models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1214265-57-2
• MW: 481.01
• Purity: 97.42% (May vary between batches)
• Formula: C₂₄H₂₅ClN₆OS
• SMILES: CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Sc3cccc(NC(=O)C=C)c3)n2)cc1
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:3 mg/mL (6.24 mM);DMSO:89 mg/mL (185.03 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ErbB-1, Epidermal growth factor receptor, EGFR (T790M), EGFR, Inhibitor, HER1, mutated, inhibit, NSCLC, WZ 8040, WZ8040, WZ-8040, phosphorylation

Quick Database Links

Gene Symbol

EGFR