XL388

SKU: orb1223368

Description

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.

Key Properties

• CAS Number: 1251156-08-7
• MW: 455.5
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₂FN₃O₄S
• SMILES: Cc1c(ccc(c1F)S(=O)(=O)C)C(=O)N1CCOc2c(C1)cc(cc2)c1cnc(cc1)N
• Target: Glucokinase
• Solubility: DMSO : 50 mg/mL. 109.77 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

XL388 | XL-388 | XL 388

Quick Database Links

Gene Symbol

Glucokinase