Y-27632 dihydrochloride

SKU: orb1307611

Description

Y-27632 dihydrochloride is a potent, cell-permeable inhibitor targeting ROCK-I and ROCK-II kinases. It is widely used in vitro to study cytoskeletal dynamics and cell adhesion, and in vivo to investigate pathways in neuroprotection, cardiovascular function, and stem cell survival.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	129830-38-2
MW	320.26
Purity	97.96% (May vary between batches)
Formula	C₁₄H₂₁N₃O·2HCl
SMILES	Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Target	ROCK,Apoptosis
Solubility	H2O:32.03 mg/mL (100.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.61 mM);DMSO:255 mg/mL (796.23 mM)

Customer Validated Data

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The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.

Success by Application

Organoid culture	1 experiment
Cell culture	2 experiments

Reactivity Distribution

Human	2 experiments
Porcine	1 experiment

Latest Experiments

3 Results

Dilution

Sample

Summary

Organoid culture

Human

10 µM

Human ameloblastoma tissue

It was used at 10 µM...

Cell culture

Porcine

5 µM

Porcine (Sus scrofa) parthenogenetic blastocysts

It was used as a ROCK...

Cell culture

Human

5 µM

Human ESC line H9

It was use as a ROCK...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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epithelial-mesenchymal, hIPSCs, Inhibitor, inhibit, lineage, mesendodermal, orally, pluripotent, modulation, Apoptosis, ATP-competitive, active, cells, Y27632, Y-27632, Y-27632 2HCl, Y27632 Dihydrochloride, Y27632 dihydrochloride, Y-27632 Dihydrochloride, Y 27632, Y 27632 Dihydrochloride, Y 27632 dihydrochloride, Rho-kinase, ROCK1 (p160ROCK), ROCK2, ROCK, ROK, Rho-associated protein kinase, Rho-associated kinase, transition-like, stem

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Quick Database Links

Gene Symbol

ROCK,Apoptosis

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