Afatinib dimaleate

SKU: orb1223861

Description

An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively; shows high selectivity over HGFR, c-Src, β-InsRK,VEGFR2; suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines and induces tumor regression in xenograft and transgenic lung cancer models.Lung Cancer Approved.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 850140-73-7
• MW: 718.0827
• Purity: >98% (HPLC)
• Formula: C₃₂H₃₃ClFN₅O₁₁
• SMILES: CN(C/C=C/C(=O)NC1=C(C=C2N=CN=C(C2=C1)NC3=CC(=C(C=C3)F)Cl)O[C@@H]4COCC4)C.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O
• Target: EGFR
• Solubility: DMSO: ≥ 35 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BIBW 2992MA2 | BIBW-2992 | BIBW2992 | BIBW 2992 | Afatinib

Quick Database Links

Gene Symbol

EGFR