Afatinib Dimaleate

SKU: orb1307469

Description

Afatinib Dimaleate is an orally active, irreversible inhibitor of the ErbB (EGFR) family of receptor tyrosine kinases. This small molecule is used in research to study oncogenic signaling and has demonstrated antitumor activity in both cellular assays and animal models of non-small cell lung cancer and other solid tumors.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 850140-73-7
• MW: 718.08
• Purity: 98.11% (May vary between batches)
• Formula: C₃₂H₃₃ClFN₅O₁₁
• SMILES: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
• Target: Autophagy,c-Met/HGFR,Akt,HER,p38 MAPK,EGFR,Apoptosis
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:252 mg/mL (350.94 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NCI-H1975, NIH-3T3 cells, NSCLC, orally active, lung cancer, HER2, HER1, Inhibitor, HKESC-1, HKESC-2, H1666, H3255, EGFR (L858R/T790M), EGFR (L858R), EGFR (wt), EC-1, EGFR, ErbB-1, Epidermal growth factor receptor, ESCC, Autophagy, Apoptosis, anticancer, BIBW 2992, BIBW 2992MA2, BIBW2992, BIBW-2992, A431, Afatinib Dimaleate, Afatinib, Afatinib (BIBW2992), Afatinib (BIBW2992) Dimaleate, Akt, c-Met/HGFR, SLMT-1, Protein kinase B, PKB, p38 MAPK

Quick Database Links

Gene Symbol

Autophagy,c-Met/HGFR,Akt,HER,p38 MAPK,EGFR,Apoptosis