AM251

SKU: orb1307120

Description

AM251 is a potent and selective cannabinoid receptor 1 (CB1) antagonist (IC50: 8 nM; Ki: 7.49 nM) with a 306-fold selectivity over CB2. It also acts as an effective GPR55 agonist (EC50: 39 nM). This compound is widely used in vitro and in vivo to investigate the endocannabinoid system in metabolic, neurological, and pain research.

Research Area

Neuroscience

Key Properties

• CAS Number: 183232-66-8
• MW: 555.24
• Purity: >98%
• Formula: C₂₂H₂₁Cl₂IN₄O
• SMILES: CC1=C(N(N=C1C(NN2CCCCC2)=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(I)C=C4
• Target: GPCR
• Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 13 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM 251, AM251, AM-251, Cannabinoid Receptor, CannabinoidReceptor, CB1, CB, inhibit, Inhibitor, GPR55

Quick Database Links

Gene Symbol

GPCR