Apoptozole

SKU: orb1222897

Description

Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.

Key Properties

• CAS Number: 1054543-47-3
• MW: 625.56
• Purity: >98% (HPLC)
• Formula: C₃₃H₂₅F₆N₃O₃
• SMILES: COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
• Target: HSC70| HSP70
• Solubility: DMSO : ≥ 31 mg/mL; 49.56 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptozole | Apoptosis Activator VII

Quick Database Links

Gene Symbol

HSC70| HSP70