APS-2-79 hydrochloride

SKU: orb1225758

Description

A small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM); binds to the KSR2-MEK1 complex and impedes the assembly of RAF–KSR–MEK complexes, suppresses KSR-stimulated MEK and ERK phosphorylation and suppresses oncogenic Ras mutations; enhances the efficacy of Trametinib against cancer cell lines containing K-Ras mutations.

Key Properties

• CAS Number: 2002381-31-7
• MW: 423.89208
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₂ClN₃O₃
• SMILES: CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.[H]Cl
• Target: MEK
• Solubility: DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

APS 2-79 hydrochloride

Quick Database Links

Gene Symbol

MEK