ARV-771

SKU: orb1301792

Description

ARV-771 is a potent PROTAC-based degrader of BET proteins, exhibiting high affinity for BRD2, BRD3, and BRD4 bromodomains with Kd values in the single-digit nanomolar range. This compound is a valuable chemical probe for investigating BET protein function in cancer research, demonstrating efficacy in both cellular assays and in vivo tumor models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1949837-12-0
• MW: 986.64
• Purity: 99.69% (May vary between batches)
• Formula: C₄₉H₆₀ClN₉O₇S₂
• SMILES: CC=1C2=C(N3C([C@H](CC(NCCOCCCOCC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C
• Target: PROTACs,Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.03 mM);DMSO:10 mM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, ARV 771, ARV771, ARV-771, BET, PROTACs

Quick Database Links

Gene Symbol

PROTACs,Epigenetic Reader Domain