Clobenpropit dihydrobromide

SKU: orb1220145

Description

Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)Clobenpropit inhibited cell migration and increased apoptosis of pancreatic cancer cells in combination with gemcitabine. Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction. Clobenpropit inhibited tumor growth (gemcitabine 294 46 mg vs combination 154 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.

Key Properties

• CAS Number: 145231-35-2
• MW: 470.7
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₉Br₂ClN₄S
• SMILES: Br.Br.Clc1ccc(CNC(=N)SCCCc2cnc[nH]2)cc1
• Target: Histamine Receptor
• Solubility: In Vitro: DMSO : 125 mg/mL (265.59 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histamine Receptor