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Curcumin

SKU: orb1308370

Description

Curcumin (Natural Yellow 3) is a specific p300/CREB histone acetyltransferase inhibitor (IC50=25 µM). This polyphenol exhibits antitumor, anti-inflammatory, and antioxidant activities, making it a valuable tool for epigenetic, cancer, and inflammation research in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Images & Validation

Key Properties

CAS Number458-37-7
MW368.38
Purity95.00% (May vary between batches)
FormulaC21H20O6
SMILESCOC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1O
TargetHDAC,Ferroptosis,Mitophagy,Epigenetic Reader Domain,Histone Acetyltransferase,Autophagy,Nrf2,Influenza Virus
SolubilityDMSO: 265.00 mg/mL (719.37 mM), Sonication is recommended. Ethanol: 1.80 mg/mL (4.89 mM), Sonication is recommended.

Customer Validated Data

The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Enzymatic glycosylation assay1 experiment
In vitro assay3 experiments
In vivo assay1 experiment
Reactivity Distribution
Chemical1 experiment
Mice1 experiment
Mouse1 experiment
Rat1 experiment
Human1 experiment

Latest Experiments

5 Results
Dilution
Sample
Summary
Enzymatic glycosylation assay
Chemical
-
Curcuma longa L. (turmeric)
For sample preparation, curcumin was dissolved...
In vitro assay
Mice
-
Mice macrophage cell line (RAW264.7)
Curcumin was dissolved and used to...
In vitro assay
Mouse
-
Mouse testicular cell lines (TM3 and TM4)
Curcumin was dissolved in dimethyl sulfoxide...
In vivo assay
Rat
-
Sprague-Dawley rat
Curcumin was prepared by dissolving it...
In vitro assay
Human
-
Human bone marrow mononuclear cells (BMMNCs)
BMMNCs were isolated from bone marrow...

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Diferuloylmethane, Curcumin, Autophagy, p300 histone acetylatransferase, Mitophagy, Mitochondrial Autophagy, Natural Yellow 3, Natural Yellow3, Natural Yellow-3, inhibit, Influenza Virus, InfluenzaVirus, Indian Saffron, Keap1-Nrf2, KEAP1-Nrf2, HAT, HATs, HistoneAcetyltransferase, Histone Acetyltransferase, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, Ferroptosis, Turmeric yellow

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

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Curcumin (orb1308370)

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5 g
$ 150.00
10 g
$ 170.00
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