Docetaxel

SKU: orb1309994

Description

Docetaxel is a semi-synthetic taxane that stabilizes microtubules, inhibiting their depolymerization with an IC50 of 0.2 µM. It promotes apoptosis by downregulating bcl-2 and bcl-xL, demonstrating potent anti-tumor activity in both cellular assays and animal models for cancer research.

Research Area

Cell Biology

Key Properties

• CAS Number: 114977-28-5
• MW: 807.9
• Purity: >98%
• Formula: C₄₃H₅₃NO₁₄
• SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Taxotere; RP-56976; NSC-628503

Quick Database Links

Gene Symbol

Cytoskeleton

Silvia Breusa a b , Eloise Thomas a , Noemi Baldinotti a , Serena Zilio a 1 , Jean-Guy Delcros c , Diana Marcela Hernandez-Palomino d , Weisha Qi e , Hanäé Guérin a , Benjamin Gibert b f , Patrick Mehlen b g , Ilaria Marigo d e , David Kryza a h , Giovanna Lollo Anti-Netrin-1 decorated nanoparticles combined with chemotherapy for the treatment of triple-negative breast cancer Biomaterials Advances, (2024)