Dolutegravir

SKU: orb1300988

Description

Dolutegravir is a potent two-metal-binding HIV-1 integrase inhibitor with an IC50 of 2.7 nM. It demonstrates intermediate antiviral activity against key raltegravir-resistant mutants, including Y143R, Q148K, N155H, and G140S/Q148H. This small molecule is widely used in antiretroviral research for both in vitro mechanistic studies and in vivo efficacy models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1051375-16-6
• MW: 419.38
• Purity: 98.97% (May vary between batches)
• Formula: C₂₀H₁₉F₂N₃O₅
• SMILES: C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
• Target: HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.87 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:84 mg/mL (200.3 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dolutegravir, inhibit, Inhibitor, Human immunodeficiency virus, HIVProtease, HIV, HIV integrase, HIV Integrase, HIV Protease, GSK 1349572, GSK1349572, GSK-1349572, S/GSK 1349572, S/GSK1349572, S/GSK-1349572

Quick Database Links

Gene Symbol

HIV Protease