Epothilone B

SKU: orb1301096

Description

Epothilone B (Patupilone) is a microtubule-stabilizing agent isolated from Sorangium cellulosum. Unlike taxanes, it retains cytotoxicity against P-glycoprotein-overexpressing multidrug-resistant cells. It is widely used in cancer research, demonstrating antitumor activity in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Cell Biology

Key Properties

• CAS Number: 152044-54-7
• MW: 507.69
• Purity: >98%
• Formula: C₂₇H₄₁NO₆S
• SMILES: C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EPO-906; EpoBI; Patupilone

Quick Database Links

Gene Symbol

Cytoskeleton