FRAX597

SKU: orb1223352

Description

FRAX597 is a potent and selective inhibitor of the p21-activated kinases. FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP-competitive Group I PAK inhibitors with significant potential for the treatment of NF2 and other cancers.

Key Properties

• CAS Number: 1286739-19-2
• MW: 558.1
• Purity: >98% (HPLC)
• Formula: C₂₉H₂₈ClN₇OS
• SMILES: CCn1c2nc(ncc2cc(c1=O)c1c(cc(cc1)c1cncs1)Cl)Nc1ccc(cc1)N1CCN(CC1)C
• Target: EGFR
• Solubility: DMSO : 14.29 mg/mL. 25.60 mM;H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FRAX597 | FRAX-597 | FRAX 597

Quick Database Links

Gene Symbol

EGFR