GNF4877

SKU: orb1218505

Description

GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.

Key Properties

• CAS Number: 2041073-22-5
• MW: 494.52
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₇FN₆O₄
• SMILES: CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCC[C@H](C4)C(=O)O)N
• Target: GSK3β|DYRK1A
• Solubility: DMSO:4.17 mg/mL (8.43 mM; Need ultrasonic and warming)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GSK3β|DYRK1A