GNF4877

SKU: orb1309621

Description

GNF4877 is a potent small molecule inhibitor of DYRK1A and GSK3β with IC50 values of 6 nM and 16 nM, respectively. It promotes β-cell proliferation by blocking NFATc nuclear export, making it a valuable research tool for studying diabetes and regenerative biology in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2041073-22-5
• MW: 494.52
• Purity: 98.63% (May vary between batches)
• Formula: C₂₅H₂₇FN₆O₄
• SMILES: CC(C)Oc1ccc(F)c(c1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](C1)C(O)=O
• Target: GSK-3,DYRK
• Solubility: DMSO:10 mg/mL (20.22 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DYRK, DYRK1A, Dual specificity tyrosine phosphorylation regulated kinase, Dual specificity tyrosine regulated kinase, GNF 4877, GNF4877, GNF-4877, Glycogen synthase kinase-3, Glycogen synthase kinase 3, GSK-3, GSK3, GSK3β, GSK-3β, Inhibitor, inhibit

Quick Database Links

Gene Symbol

GSK-3,DYRK