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GSK4112

SKU: orb1226777

Description

A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay; mediates the repression of Rev-erbα target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.

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Key Properties

CAS Number1216744-19-2
MW396.8883
Purity>98% (HPLC)
FormulaC18H21ClN2O4S
SMILESO=C(OC(C)(C)C)CN(CC1=CC=C(Cl)C=C1)CC2=CC=C([N+]([O-])=O)S2
TargetAutophagy
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SR6452 | GSK-4112 | GSK 4112 | SR-6452 | SR 6452

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GSK4112 (orb1226777)

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$ 90.00
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$ 140.00
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