GSK4112

SKU: orb1302143

Description

GSK4112 (SR6452) is a potent and selective synthetic agonist of the nuclear receptor Rev-erbα, demonstrating an EC50 of 0.4 μM. This chemical probe is widely used in vitro and in vivo to investigate circadian rhythm regulation, metabolic pathways, and inflammatory responses linked to Rev-erbα biology.

Research Area

Cell Biology

Key Properties

• CAS Number: 1216744-19-2
• MW: 396.9
• Purity: >98%
• Formula: C₁₈H₂₁ClN₂O₄S
• SMILES: CC(C)(C)OC(=O)CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1
• Target: Transcription factor
• Solubility: Soluble in DMSO (50 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR-6452

Quick Database Links

Gene Symbol

Transcription factor