H3B-5942

SKU: orb1225733

Description

H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA), demonstrates potent ERαantagonist activity in vitro and in vivo; covalently inactivates both wild-type and mutant ERα by targeting Cys530 and enforcing a unique antagonist conformation; demonstrated significant single-agent antitumor activity in xenograft models representing ERαWT and ERα Y537S breast cancer that was superior to fulvestrant.

Key Properties

• CAS Number: 2052128-15-9
• MW: 494.639
• Purity: >98% (HPLC)
• Formula: C₃₁H₃₄N₄O₂
• SMILES: CCC(=C(C1=CC=C(C=C1)OCCNCC=CC(=O)N(C)C)C2=CC3=C(C=C2)NN=C3)C4=CC=CC=C4
• Target: Estrogen Receptor/ERR
• Solubility: In Vitro: DMSO : 83.33 mg/mL (168.47 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H3B5942

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR