IM-12

SKU: orb1305870

Description

IM-12 is a potent and selective small molecule inhibitor of GSK-3β with an IC₅₀ of 53 nM. It acts as a canonical Wnt/β-catenin pathway activator and is a valuable chemical tool for studying Wnt signalling in stem cell biology, oncology, and neurological research, both in vitro and in vivo.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1129669-05-1
• MW: 377.4
• Purity: >98%
• Formula: C₂₂H₂₀FN₃O₂
• SMILES: CN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c1c(C)[nH]c2ccccc12
• Target: Kinase
• Solubility: Soluble in DMSO (50 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3β, GSK3, GSK-3, inhibit, IM-12, IM 12, IM12

Quick Database Links

Gene Symbol

Kinase