JAK3-IN-2

SKU: orb1226269

Description

A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM; dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1443235-95-7
• MW: 350.378
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₄O₃
• SMILES: O=C(C1=CNC2=NC=NC(C3=CC=CC(NC(C(C)=C)=O)=C3)=C21)OCC
• Target: JAK
• Solubility: In Vitro: DMSO : 260 mg/mL (742.07 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JAK3 inhibitor 2

Quick Database Links

Gene Symbol

JAK