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JZL184

SKU: orb1222875

Description

JZL184 is highly selective, and potent MAGL inhibitor ( monoacylglycerol lipase inhibitor). JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. JZL184 also suppresses inflammatory pain in the mouse carrageenan model.

Images & Validation

Key Properties

CAS Number1101854-58-3
MW520.49
Purity>98% (HPLC)
FormulaC27H24N2O9
SMILESOC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+](=O)[O-])(c1ccc2OCOc2c1)c1ccc2OCOc2c1
TargetMAGL
SolubilityDMSO : ≥ 35 mg/mL; 67.24 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JZL184 | JZL 184 | JZL-184

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JZL184 (orb1222875)

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$ 70.00
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