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Ki20227

SKU: orb1224427

Description

A potent, selective, orally active c-Fms inhibitor with IC50 of 2 nM; weakly inhibits KDR, c-Kit, and PDGFRβ with IC50 of 12, 451, and 217 nM, respectively, no activty against Flt-3, c-Src, Fyn, EGFR, FGFR2, Met, Btk, PKA, and PKCα (IC50>1,000 nM); inhibits the M-CSF-dependent cell growth, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

Images & Validation

Key Properties

CAS Number623142-96-1
MW480.5362
Purity>98% (HPLC)
FormulaC24H24N4O5S
SMILESO=C(NC(C1=NC=CS1)C)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2OC
TargetCSF1R
SolubilityDMSO: 7.2 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ki 20227 | Ki-20227

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  • Ki20227 [orb1302959]

    97.16% (May vary between batches)

    623142-96-1

    480.54

    C24H24N4O5S

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Ki20227 (orb1224427)

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Available Sizes

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2 mg
$ 110.00
5 mg
$ 170.00
10 mg
$ 270.00
25 mg
$ 500.00
50 mg
$ 880.00
100 mg
$ 1,220.00
500 mg
$ 2,440.00