Ki20227

SKU: orb1302959

Description

Ki-20227 is a potent and selective small molecule inhibitor of the c-Fms/CSF1R tyrosine kinase with an IC50 of 2 nM. It also exhibits activity against VEGFR2 and c-Kit/PDGFRβ. This inhibitor is a valuable research tool for studying tumor-associated macrophages, angiogenesis, and related oncogenic pathways in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 623142-96-1
• MW: 480.54
• Purity: 97.16% (May vary between batches)
• Formula: C₂₄H₂₄N₄O₅S
• SMILES: COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1
• Target: VEGFR,c-Fms,c-Kit,CSF-1R,PDGFR
• Solubility: DMSO:55 mg/mL (114.45 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CSF-1 receptor, CSF1R, CSF-1R, CD117, c-Fms, cFms, colony stimulating factor 1 receptor, cKit, c-Kit, Inhibitor, Platelet-derived growth factor receptor, Ki 20227, Ki-20227, Ki20227, inhibit, SCFR, PDGFR, Vascular endothelial growth factor receptor, VEGFR, VEGFR2

Quick Database Links

Gene Symbol

VEGFR,c-Fms,c-Kit,CSF-1R,PDGFR