MKT-077

SKU: orb1226208

Description

MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53; induces release of wild-type p53 from cytoplasmically sequestered p53-mot-2 complexes and rescued its transcriptional activation function; also is a potent telomerase inhibitor with IC50 of 5 uM.

Key Properties

• CAS Number: 147366-41-4
• MW: 432
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂ClN₃OS₂
• SMILES: O=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C/C4=CC=CC=[N+]4CC.[Cl-]
• Target: HSP
• Solubility: DMSO: 20 mg/mL; Water: 20 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FJ-776

Quick Database Links

Gene Symbol

HSP