MMAF

SKU: orb1304379

Description

MonoMethyl auristatin F (MMAF) is a potent antimitotic agent that disrupts microtubule dynamics by inhibiting tubulin polymerization, thereby arresting cell division. This mechanism makes it a valuable payload in antibody-drug conjugates (ADCs) for cancer research, with applications in both in vitro cytotoxicity assays and in vivo xenograft studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 745017-94-1
• MW: 731.96
• Purity: 97.00% (May vary between batches)
• Formula: C₃₉H₆₅N₅O₈
• SMILES: CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
• Target: Microtubule Associated,ADC Cytotoxin
• Solubility: DMSO:250 mg/mL (341.55 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Payload, ADCCytotoxin, ADC Cytotoxin, Cytotoxicity( Karpas 299 cell), Inhibitor, MonoMethyl auristatin F, Monomethylauristatin F, MMAF, Microtubule Associated, Microtubule/Tubulin, MicrotubuleAssociated, inhibit

Quick Database Links

Gene Symbol

Microtubule Associated,ADC Cytotoxin