Mutated EGFR-IN-1

SKU: orb1307999

Description

Mutated EGFR-IN-1, an analog of Osimertinib, serves as a key chemical intermediate for developing inhibitors targeting oncogenic EGFR mutants including L858R, exon 19 deletions, and the resistant T790M variant. It is utilized in preclinical research for both in vitro enzymatic assays and in vivo efficacy studies in relevant xenograft models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1421372-66-8
• MW: 445.56
• Purity: 98.91% (May vary between batches)
• Formula: C₂₅H₃₁N₇O
• SMILES: COc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
• Target: EGFR
• Solubility: DMSO:7.5 mg/mL (16.83 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mutated EGFRIN1, Mutated EGFR-IN-1, Mutated EGFR IN 1, inhibit, Osimertinib, Osimertinib analog, EGFR, EGFR (L858R), EGFR (T790M), EGFR(Exon 19 deletion/T790M), EGFRT790M, EGFRExon 19 deletion/T790M, EGFRL858R, Epidermal growth factor receptor, ErbB-1, Inhibitor, HER1

Quick Database Links

Gene Symbol

EGFR