Niraparib

SKU: orb1304399

Description

Niraparib (MK-4827) is a potent and selective PARP1/2 inhibitor (IC50=3.8/2.1 nM) that impedes DNA repair, leading to apoptosis. It is widely used in oncology research, demonstrating antitumor efficacy in both cellular assays and in vivo models of BRCA-mutated and homologous recombination-deficient cancers.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1038915-60-4
• MW: 320.39
• Purity: 98.00% (May vary between batches)
• Formula: C₁₉H₂₀N₄O
• SMILES: C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1
• Target: Apoptosis,PARP
• Solubility: DMSO:65.63 mg/mL (204.84 mM);Ethanol:60 mg/mL (187.27 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:6 mg/mL (18.73 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast, damage, DNA, bioavailable, cancer, Apoptosis, anti-tumor, Inhibitor, MK-4827, MK4827, MK 4827, PARP2, PARP3, PARP1, PARP, ovarian, poly ADP ribose polymerase, Niraparib, orally, inhibit, lung, TANK-1, V-PARP

Quick Database Links

Gene Symbol

Apoptosis,PARP