NLRP3-IN-9

SKU: orb1304981

Description

NLRP3-IN-9 (INF-4E) is a covalent NLRP3 ATPase inhibitor that blocks caspase-1 activation. It suppresses ATP- and nigericin-induced pyroptosis in human THP-1 cells in a time- and concentration-dependent manner. This inhibitor is a valuable tool for studying NLRP3 inflammasome biology in cellular models of inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 88039-46-7
• MW: 240.68
• Purity: 98.51% (May vary between batches)
• Formula: C₁₂H₁₃ClO₃
• SMILES: CCOC(=O)C(=C)C(O)c1ccccc1Cl
• Target: NOD,NOD-like Receptor (NLR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.31 mM);DMSO:60 mg/mL (249.29 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, NLRP3, NLRP3 IN 9, NLRP3IN9, NLRP-3-IN-9, NLRP3-IN-9, NOD-like Receptor (NLR), inhibit, inflammasome, INF4E, INF-4E, INF 4E, myocardial injury, caspase-1, dysfunction, pyroptosis, THP-1 cells

Quick Database Links

Gene Symbol

NOD,NOD-like Receptor (NLR)