Phloretin

SKU: orb1304838

Description

Phloretin (NSC-407292) is a natural dihydrochalcone and a potent inhibitor of eukaryotic urea transporters, notably blocking VacA-mediated transport. It exhibits strong antioxidative properties and has demonstrated in vitro efficacy in inhibiting proliferation and inducing apoptosis in various cancer cell lines, including B16 melanoma and HL60 leukemia cells.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60-82-2
• MW: 274.27
• Purity: 98.53% (May vary between batches)
• Formula: C₁₅H₁₄O₅
• SMILES: C(CCC1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2O
• Target: Urea Transporter,SGLT,transporter,Endogenous Metabolite
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.03 mM);Ethanol:48 mg/mL (175.01 mM);DMSO:80 mg/mL (291.68 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dihydronaringenin, NSC407292, NSC-407292, NSC 407292, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, GLUT, Glucose transporter, Sodium-dependent glucose cotransporters, RJC 02792, RJC02792, RJC-02792, Phloretin, SGLT1, SGLT, SGLT2

Quick Database Links

Gene Symbol

Urea Transporter,SGLT,transporter,Endogenous Metabolite