Pilaralisib

SKU: orb1305590

Description

Pilaralisib (XL-147) is a selective, orally bioavailable phosphoinositide-3 kinase (PI3K) inhibitor. It has been widely employed in preclinical and clinical research, including in vitro cell-based assays and in vivo xenograft models, to investigate its therapeutic potential in cancers such as breast cancer, lymphoma, and glioblastoma.

Research Area

Signal Transduction

Key Properties

• CAS Number: 934526-89-3
• MW: 541.02
• Purity: 98.24% (May vary between batches)
• Formula: C₂₅H₂₅ClN₆O₄S
• SMILES: COc1ccc(Cl)c(Nc2nc3ccccc3nc2NS(=O)(=O)c2cccc(NC(=O)C(C)(C)N)c2)c1
• Target: PI3K
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:93 mg/mL (171.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.1 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, SAR 245408, SAR245408, SAR-245408, PI3K, Phosphoinositide 3-kinase, XL 147, XL-147, XL147, PI3Kδ, PI3Kβ, PI3Kγ, PI3Kα, Pilaralisib

Quick Database Links

Gene Symbol

PI3K