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PNU 282987

SKU: orb1222797

Description

PNU-282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). PNU-282987 is inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).

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Key Properties

CAS Number123464-89-1
MW301.21
Purity>98% (HPLC)
FormulaC14H18Cl2N2O
SMILESCl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
TargetAChR
SolubilityDMSO : ≥ 61 mg/mL 202.52 mM; H2O : 50 mg/mL 166.00 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PNU-282987 | PNU 282987

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PNU 282987 (orb1222797)

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500 mg
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