PNU-282987

SKU: orb1305505

Description

PNU-282987 is a potent and selective agonist for the α7 nicotinic acetylcholine receptor (α7 nAChR), exhibiting a Ki of 26 nM. It shows negligible affinity for α1β1γδ and α3β4 nAChR subtypes (IC50 ≥ 60 μM). This compound is widely used in neuroscience research to investigate α7 nAChR function in cognitive and neuropsychiatric disorders, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 123464-89-1
• MW: 301.21
• Purity: 99.00% (May vary between batches)
• Formula: C₁₄H₁₈Cl₂N₂O
• SMILES: Cl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
• Target: 5-HT Receptor,AChR
• Solubility: H2O:25 mg/mL (83 mM);10% DMSO+90% Corn Oil:1.67 mg/mL (5.54 mM);DMSO:250 mg/mL (829.99 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, nAChR, Nicotinic acetylcholine receptors, Inhibitor, α7 nAChR, PNU282987, PNU-282987, PNU 282987

Quick Database Links

Gene Symbol

5-HT Receptor,AChR