SB 415286

SKU: orb1300580

Description

SB 415286 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3), exhibiting IC₅₀ values of 78 nM and 31 nM for GSK-3α and GSK-3β, respectively. This cell-permeable compound is widely used in vitro and in vivo to investigate GSK-3's role in Wnt/β-catenin signaling, neurodegenerative diseases, and glucose metabolism.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 264218-23-7
• MW: 359.72
• Purity: 99.55% (May vary between batches)
• Formula: C₁₆H₁₀ClN₃O₅
• SMILES: Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl
• Target: Apoptosis,GSK-3
• Solubility: DMSO:18 mg/mL (50.04 mM);Ethanol:9 mg/mL (25.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.56 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK-3α/β, GSK-3, GSK3, Glycogen synthase kinase-3, Glycogen synthase kinase 3, Inhibitor, inhibit, Apoptosis, SB 415286, SB415286, SB-415286

Quick Database Links

Gene Symbol

Apoptosis,GSK-3