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SB415286

SKU: orb1223168

Description

SB-415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes.

Images & Validation

Key Properties

CAS Number264218-23-7
MW359.72
Purity>98% (HPLC)
FormulaC16H10ClN3O5
SMILESOC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C2=C(C=CC=C2)[N+]([O-])=O)C=C1
TargetCDK
SolubilityDMSO : ≥ 83.3 mg/mL; 231.57 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SB-415286 | SB 415286 | SB415286

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  • SB 415286 [orb1300580]

    99.55% (May vary between batches)

    264218-23-7

    359.72

    C16H10ClN3O5

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SB415286 (orb1223168)

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200 mg
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2 mg
$ 70.00
5 mg
$ 90.00
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$ 260.00
50 mg
$ 460.00
100 mg
$ 670.00