SKI II

SKU: orb1222379

Description

SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells.

Key Properties

• CAS Number: 312636-16-1
• MW: 302.78
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₁ClN₂OS
• SMILES: c1cc(ccc1c1csc(n1)Nc1ccc(cc1)O)Cl
• Target: SphK1
• Solubility: DMSO : ≥ 100 mg/mL; 330.27 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKI-II | SKI II. Sphingosine kinase inhibitor II

Quick Database Links

Gene Symbol

SphK1