SKI II

SKU: orb1300568

Description

SKI-II is a potent and selective non-ATP-competitive inhibitor of sphingosine kinase 1 (SphK1) with an IC50 of 0.5 µM, showing no activity against PKCα, PI3K, or ERK2. This tool compound is widely used in vitro and in vivo to investigate the S1P signaling pathway in cancer, inflammation, and angiogenesis research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 312636-16-1
• MW: 302.78
• Purity: 99.34% (May vary between batches)
• Formula: C₁₅H₁₁ClN₂OS
• SMILES: Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1
• Target: Apoptosis,Wnt/beta-catenin,S1P Receptor
• Solubility: DMSO:40 mg/mL (132.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S1PReceptor, S1P Receptor, SKI II, Sphingosine kinase, SphK-I2, SphK1, SphK, Wnt/b-catenin, Wnt, Wnt/β-catenin, Wnt/betacatenin, βcatenin, inhibit, Inhibitor, beta-catenin, betacatenin, bcatenin, Apoptosis

Quick Database Links

Gene Symbol

Apoptosis,Wnt/beta-catenin,S1P Receptor