SNX 2112

SKU: orb1223685

Description

SNX 2112 (PF 04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β; shows weak affinity for Hsp90 family members Grp94 and Trap-1 (IC50=0.8-4.2 uM); has properties and potency, including degradation of HER2, mutant EGFR, and other client proteins, inhibition of ERK and Akt activation, and induction of a Rb-dependent G1 arrest with subsequent apoptosis; the orally bioavailbe prodrug SNX-5422, inhibits MM cell growth and prolongs survival in a xenograft murine model.

Key Properties

• CAS Number: 908112-43-6
• MW: 464.489
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₇F₃N₄O₃
• SMILES: O=C(N)C1=CC=C(N2N=C(C(F)(F)F)C3=C2CC(C)(C)CC3=O)C=C1N[C@H]4CC[C@H](O)CC4
• Target: HSP
• Solubility: DMSO: 86 mg/mL (185.2 mM); Ethanol: 1 mg/mL (2.15 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF 04928473

Quick Database Links

Gene Symbol

HSP