Sonidegib

SKU: orb1307090

Description

Sonidegib (Erismodegib) is a potent and selective Smoothened (Smo) antagonist that blocks Hedgehog (Hh) signaling, exhibiting IC50 values of 1.3 nM in mouse and 2.5 nM in human assays. This inhibitor is widely used in cancer research, particularly for studying basal cell carcinoma, in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 956697-53-3
• MW: 485.5
• Purity: 98.00% (May vary between batches)
• Formula: C₂₆H₂₆F₃N₃O₃
• SMILES: CC1=C(C=CC=C1C(NC=2C=CC(=NC2)N3C[C@@H](C)O[C@@H](C)C3)=O)C4=CC=C(OC(F)(F)F)C=C4
• Target: Hedgehog/Smoothened,Smo
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.3 mM);Ethanol:90 mg/mL (185.38 mM);DMSO:255 mg/mL (525.23 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sonidegib, Smoothened, Smo, Erismodegib, Inhibitor, Hedgehog, LDE 225, LDE225, LDE-225, NVP-LDE 225, NVP-LDE225, NVP-LDE-225, inhibit

Quick Database Links

Gene Symbol

Hedgehog/Smoothened,Smo