Sunitinib

SKU: orb1310675

Description

Sunitinib (SU11248) is a multi-targeted receptor tyrosine kinase inhibitor with potent activity against VEGFR2 and PDGFRβ (IC50=80/2 nM). It exhibits antitumor effects and is used in research on renal cell carcinoma and gastrointestinal stromal tumors, supported by both in vitro and in vivo studies.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 557795-19-4
• MW: 398.47
• Purity: 98.00% (May vary between batches)
• Formula: C₂₂H₂₇FN₄O₂
• SMILES: C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3
• Target: Autophagy,FLT,c-Kit,IRE1,PDGFR,VEGFR,Mitophagy,Apoptosis
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.25 mg/mL (3.14 mM);DMSO:25 mg/mL (62.74 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Autophagy, cKit, c-Kit, inhibit, IRE1, Platelet-derived growth factor receptor, Mitophagy, Mitochondrial Autophagy, Inositol requiring enzyme 1, Inhibitor, FLT3, SU 11248, SU11248, SU-11248, Sunitinib, PDGFR, PDGFRβ, VEGFR2, VEGFR, Vascular endothelial growth factor receptor

Quick Database Links

Gene Symbol

Autophagy,FLT,c-Kit,IRE1,PDGFR,VEGFR,Mitophagy,Apoptosis

Ryan Tsz-Hei Tse 1, Christine Yim-Ping Wong 1, Xiaofan Ding 2, Carol Ka-Lo Cheng 1, Chit Chow 3, Ronald Cheong-Kin Chan 3, Joshua Hoi-Yan Ng 4, Victor Wai-Lun Tang 4, Peter Ka-Fung Chiu 1, Jeremy Yuen-Chun Teoh 1, Nathalie Wong 2, Ka-Fai To 3, Chi-Fai Ng The establishment of kidney cancer organoid line in drug testing Cancer Med, (2024)

PubMed: 38923304

Applications

Cell Culture