T0901317

SKU: orb1225409

Description

A potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively); upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism; decreases amyloid-β production in primary neurons in vitro; displays an EC50 of ~ 5 μM for activation of FXRs.Alzheimer's Disease Discontinued.

Key Properties

• CAS Number: 293754-55-9
• MW: 481.3327
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₂F₉NO₃S
• SMILES: OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
• Target: LXR
• Solubility: DMSO: ≥ 27 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T 0901317 | T-0901317

Quick Database Links

Gene Symbol

LXR