Thapsigargin

SKU: orb1296066

Description

Thapsigargin is a natural SERCA inhibitor that disrupts calcium homeostasis by blocking Ca2+ uptake into the ER/SR, leading to elevated cytosolic Ca2+ and ER stress. It is widely used in vitro and in vivo to study apoptosis, autophagy, and ER stress signaling pathways in cancer and neurodegenerative disease research.

Research Area

Cell Biology

Key Properties

• CAS Number: 67526-95-8
• MW: 650.77
• Purity: >98%
• Formula: C₃₄H₅₀O₁₂
• SMILES: O(C(CCCCCCC)=O)[C@H]1[C@]2(C([C@]3([C@](O)([C@@H](OC(CCC)=O)C[C@@]2(OC(C)=O)C)[C@](C)(O)C(=O)O3)[H])=C(C)[C@@H]1OC(/C(=C\C)/C)=O)[H]
• Target: ATPase
• Solubility: Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

unfolded, protein ,response, SARSCoV, SARS coronavirus, SARS-CoV, stress, Thapsigargin, inhibit, Inhibitor, Apoptosis, CalciumChannel, Ca2+ channels, Ca2+-ATPase, Calcium Channel, Ca channels, coronavirus

Quick Database Links

Gene Symbol

ATPase