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VER-49009

SKU: orb1221619

Description

VER-49009 is a potent HSP90 inhibitor. VER-49009 inhibits Hsp90 with an IC50 value of 47 nM. VER-49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

Images & Validation

Key Properties

CAS Number558640-51-0
MW387.82
Purity>98% (HPLC)
FormulaC19H18ClN3O4
SMILESc1(c(cc(c(c1)c1c(c([nH]n1)C(=O)NCC)c1ccc(cc1)OC)O)O)Cl
TargetFactor Xa
SolubilityDMSO : 100 mg/mL 257.85 mM;H2O : < 0.1 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VER49009 | VER 49009 | VER-49009

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VER-49009 (orb1221619)

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2 mg
$ 120.00
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$ 260.00
25 mg
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100 mg
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200 mg
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500 mg
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